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I got it working, IIRC, I followed this guide and added the following:

environment.systemPackages = [  
pkgs.uv
]

programs.nix-ld = {
enable = true;
libraries = [ config.boot.kernelPackages.nvidia_x11 ]; 
}

My nvidia config:

  hardware = {
    graphics.enable = true;
    nvidia = {
      nvidiaSettings = true;
      open = true;
    };
  };

I looked at this comfyui issue, then downloaded comfyui and ran these commands in the directory: uv add --requirements requirements.txt, uv sync --extra cu126.

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@Oneechan69
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@edwardsdigital
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